1500 newly identified genes that might unravel the human aging secret

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Human Aging Timeline http://montanamedicalaesthetics.com/services-3/aging-timeline/
Human Aging Timeline

Dr. Joseph Powell from University of Queensland together with Dr. Joyce van Meurs and Dr. Andrew Johnson recently identified nearly 1500 genes that are associated with aging. Their groundbreaking discovery could lead to improved prevention and probably treatment for age-related disease.

By studying gene activity levels in the blood of over 15,000 people, the research team pinpointed 1497 age-associated genes, the function of which were previously either unknown or not linked with aging. They elucidated the link between the gene activity and aging, and identified the genes that got more or less active as people became older.

“This information could be used to predict people who are at risk relative to their age for disease, and allow people to make lifestyle and environmental changes to mitigate that risk. While an anti-ageing treatment is still well into the future, this work could provide a roadmap for developing new treatments for age-related diseases,” said by Dr. Powell.

The research team further developed a new method to predict human biological age based on the gene activity profile, and incorporated it into a website. Participants with a higher biological age than their actual chronological age suggesting an increased disease risk profile, and vice versa. The study further suggested that the enhancer region of DNA also plays a role in the change of gene activity level.

“This study has illuminated some of the underlying molecular mechanisms that cause your disease susceptibility to rise as you age, opening new avenues for future studies,” Dr Powell said.

Source: UQ News.