A Paradox: Polyphenols in alcoholic beverages actually help alleviate alcoholic fatty liver!

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Source: Pixabay
Source: Pixabay

An interesting new publication in Plos One talks about how polyphenols in alcoholic beverages actually help to alleviate alcoholic fatty liver. The researchers from Japan, who performed this study, wanted to elucidate the effect of the polyphenols contained in alcoholic beverages on the metabolic stress induced by ethanol consumption. They fed four groups of mice for five weeks with a liquid diet with or without ethanol, with ethanol plus ellagic acid (a potent antioxidant found in fruits and vegetables) and with ethanol plus trans-resveratrol  (a type of natural phenol). Results showed that the mice fed on ethanol diet had increased incidence of fatty liver, while the other groups did not show any signs of liver damage. Moreover, expression of genes involved in cell stress were significantly up-regulated in the ethanol fed mice group alone. On the other hand, the polyphenol treated group showed increased expression of genes involved in bile acid synthesis, unsaturated fatty acid elongation and tetrahydrofolate formation; all these genes were down-regulated in the ethanol-only group. This study provides a molecular basis for the prevention of alcohol-induced stress by the polyphenols in alcoholic beverages.

 The original publication can be accessed here.

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Scientist-entrepreneur-manager-journalist: -Co-founder, Author; Former Assistant Editor and Director, Biotechin.Asia, Biotech Media Pte. Ltd.; -Founder & CEO, SciGlo (www.sciglo.com); -Programme Management Officer, SBIC, A*STAR (former Research Fellow). --Sandhya graduated from University of Madras, India (B.Sc Microbiology and M.Sc Biotechnology) and received her Ph.D from the Nanyang Technological University, Singapore. She worked on oxidative stress in skin, skeletal, adipose tissue and cardiac muscle for a decade from 2006-2016. She is currently working as a Programme Management Officer handling projects and grants at Singapore Bioimaging Consortium (SBIC), Agency for Science, Technology and Research (A*STAR). Earlier to this she was a Research Fellow in the Fat Metabolism and Stem Cell Group at SBIC. Sandhya was also the Vice President and Publicity Chair of A*PECSS (A*STAR Post Doc Society) (2014-2016). Recently she founded a platform for scientists - SciGlo (www.sciglo.com) and is a startup mentor at Vertical VC (Finland). She is an ardent lover of science and enjoys globe trotting and good vegetarian food.

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