Scientists ‘tame’ genetically modified bacteria

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Image: E.coli bacteria (Source: http://phys.org/news/2013-05-environment-patterns-emerge-tracks-coli.html)
A Rice University lab built computer models of the regulatory networks in E. coli bacteria to understand how networks develop without environmental intervention. Credit: Rice University/Photos.com

The world is definitely skeptical about genetically modified organisms and wondering about the risk of these organisms escaping into the environment. These organisms are already producing insulin and other drug ingredients, helping produce biofuels, teaching scientists about human disease and improving fishing and agriculture. While the risks can be exaggerated, modified organisms do have the potential to upset natural ecosystems, if they were to escape. Physical containment alone is not enough. Lab dishes and industrial vats can break; workers can go home with inadvertently contaminated clothes and so on.

Two teams from USA have produced genetically modified (GM) bacteria that depend on a protein building block — an amino acid — that does not occur in nature. Both these research studies were published in the highly acclaimed journal Nature. The bacteria thrive in the laboratory, growing robustly as long as the unnatural amino acid is included in their diet. But several experiments involving 100 billion or more cells and lasting up to 20 days did not reveal a single microbe capable of surviving in the absence of the artificial supplement. “Our strains, to the extent that we can test them, won’t escape,” says Dan Mandell, a synthetic biologist at Harvard Medical School in Boston, Massachusetts, and an author on one of the two studies describing the strategy. The microbes also do not swap their engineered DNA with natural counterparts because they no longer speak life’s shared biochemical language. “Establishing safety and security from the get-go will really enable broad and open use of engineered organisms,” says Farren Isaacs, a synthetic biologist at Yale University in New Haven, Connecticut, who led the other study. Synthetic amino acids/proteins are the answer to not let the genetically modified organisms out into the ‘wild’.

The original publications can be read at:

http://bit.ly/1CSNMLc

http://bit.ly/15wtLPi

Disclaimer: This articles does not reflect any personal views of the authors/editors

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Scientist-entrepreneur-manager-journalist: -Co-founder, Author; Former Assistant Editor and Director, Biotechin.Asia, Biotech Media Pte. Ltd.; -Founder & CEO, SciGlo (www.sciglo.com); -Programme Management Officer, SBIC, A*STAR (former Research Fellow). --Sandhya graduated from University of Madras, India (B.Sc Microbiology and M.Sc Biotechnology) and received her Ph.D from the Nanyang Technological University, Singapore. She worked on oxidative stress in skin, skeletal, adipose tissue and cardiac muscle for a decade from 2006-2016. She is currently working as a Programme Management Officer handling projects and grants at Singapore Bioimaging Consortium (SBIC), Agency for Science, Technology and Research (A*STAR). Earlier to this she was a Research Fellow in the Fat Metabolism and Stem Cell Group at SBIC. Sandhya was also the Vice President and Publicity Chair of A*PECSS (A*STAR Post Doc Society) (2014-2016). Recently she founded a platform for scientists - SciGlo (www.sciglo.com) and is a startup mentor at Vertical VC (Finland). She is an ardent lover of science and enjoys globe trotting and good vegetarian food.