Cerebral artery dilation can be caused by reactive oxygen species

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Scientists from USA and Canada have discovered that calcium-permeable channels are present in cerebral arteries, which are colocalized with NADPH oxidase 2, a potent inducer of reactive oxygen species (ROS) in various cells. The scientists coined the term “TRPA1 sparklets” based on their discovery of ROS-triggered calcium signals representing calcium influx through single TRPA1 (transient receptor potential ankyrin 1) channels. In the publication in Science Signaling, they say that “TRPA1 sparklet activity was low under basal conditions but was stimulated by NOX-generated ROS. Ca2+ entry during a single TRPA1 sparklet was twice that of a TRPV4 sparklet and ~200 times that of an L-type Ca2+ channel sparklet. The NADPH oxidase-induced TRPA1 sparklets activated intermediate-conductance, Ca2+-sensitive K+ channels, resulting in smooth muscle hyperpolarization and vasodilation.” From their data, it comes to our knowledge that during circulation, cerebral arteries dilate due to lipid peroxidation metabolites generated by ROS activated Ca2+ influx through TRPA1 channels in the endothelium.

The article can be accessed at: http://stke.sciencemag.org/content/8/358/ra2.abstract

Disclaimer: This article does not reflect any personal views of the authors/editors

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Scientist-entrepreneur-manager-journalist: -Co-founder, Author; Former Assistant Editor and Director, Biotechin.Asia, Biotech Media Pte. Ltd.; -Founder & CEO, SciGlo (www.sciglo.com); -Programme Management Officer, SBIC, A*STAR (former Research Fellow). --Sandhya graduated from University of Madras, India (B.Sc Microbiology and M.Sc Biotechnology) and received her Ph.D from the Nanyang Technological University, Singapore. She worked on oxidative stress in skin, skeletal, adipose tissue and cardiac muscle for a decade from 2006-2016. She is currently working as a Programme Management Officer handling projects and grants at Singapore Bioimaging Consortium (SBIC), Agency for Science, Technology and Research (A*STAR). Earlier to this she was a Research Fellow in the Fat Metabolism and Stem Cell Group at SBIC. Sandhya was also the Vice President and Publicity Chair of A*PECSS (A*STAR Post Doc Society) (2014-2016). Recently she founded a platform for scientists - SciGlo (www.sciglo.com) and is a startup mentor at Vertical VC (Finland). She is an ardent lover of science and enjoys globe trotting and good vegetarian food.