Remember your parents nagging you to wear your jacket, coat and probably a scarf or a cap when you go outside in the cold? Well, they were right. A study published very recently in Proceedings of the National Academy of Sciences proves that the common cold virus, Rhinovirus, grows more rapidly at cooler temperatures. The researchers found that in mouse airway cells, the common cold virus limits its replication at warm temperatures due to temperature-dependent innate defense system. Most Rhinoviruses are known to replicate better at 33-35˚C, which is found in the nasal cavity, rather than in the body’s core temperature of 37˚C.
Using a mouse-adapted virus, the scientists from Yale University, Connecticut found that “airway epithelial cells supporting rhinovirus replication, initiate a more robust antiviral defense response through RIG-I–like receptor (RLR)–dependent interferon secretion and enhanced interferon responsiveness at lung temperature vs. nasal cavity temperature.” So don’t forget to cover yourselves when its chilly!
To access the full article, please click on the link: http://www.pnas.org/content/early/2015/01/02/1411030112
Disclaimer: This article does not reflect any personal views of authors/editors