The recent article, ‘Inflammation’s stop signals’, published in the highly esteemed journal, Science, talks about how the body systematically shuts down inflammatory signals. In the case of an infection, entry of a pathogen or an injury, inflammation is unavoidable and highly important. But there is definitely a need to stop the inflammatory signals at some point. Until now, researchers thought that there was no evident stop signal and the body gradually stops inflammation once the stimulus is removed. But the present study proves that there is and it is of course, produced by the human body itself. A myriad of molecules including Lipoxins, Protectins, Resolvins, Maresins, H2S, Annexin A1, Macrophages, nerve cells and endothelial cells are actively involved in the process of shutting down inflammation by targeting various cells thus promoting tissue healing.
Dr. Charles Serhan, Professor of Anaesthesia at Harvard Medical School, Director and Principal Investigator and NIH Program Project Program Director and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine, and his group explored the molecular signals used by the body to naturally shut down inflammation. His brush with death in 1990, due to a hole in his intestine during a trip to Asia, encouraged him to do this study. This could prove beneficial to therapies as we would then know which molecule or which signaling pathway to manipulate to reduce inflammation.
The original article can be accessed at: http://www.sciencemag.org/content/347/6217/18
Disclaimer: This article does not reflect any personal views of the authors/editors