Get your kids to eat their Broccoli!

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Karima Djabali’s group from Technische Universität Münche (TUM), Germany and other scientists from USA have found out that Sulforaphane, found in young broccoli sprouts, enhances the clearance of progerin in Hutchinson-Gilford progeria syndrome (HGPS). HGPS is a rare disorder characterized by premature aging with rapid growth deceleration in childhood and is due to a point mutation in the lamin A gene resulting in a truncated protein called progerin. Their study suggests that consumption of broccoli would increase the intake of Sulforaphane, a potent inducer of anti-oxidant enzymes. These enzymes would reduce the oxidative stress, which is enhanced in HGPS. Also, Sulforaphane enhanced the protein degradation of progerin, reduced the levels of DNA damage and improved the nuclear morphology of HGPS fibroblasts. The results of this study were published on 16th December 2014 in the leading journal, Aging cell.

The original article can be read at: http://onlinelibrary.wiley.com/doi/10.1111/acel.12300/full

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Scientist-entrepreneur-manager-journalist: -Co-founder, Author; Former Assistant Editor and Director, Biotechin.Asia, Biotech Media Pte. Ltd.; -Founder & CEO, SciGlo (www.sciglo.com); -Programme Management Officer, SBIC, A*STAR (former Research Fellow). --Sandhya graduated from University of Madras, India (B.Sc Microbiology and M.Sc Biotechnology) and received her Ph.D from the Nanyang Technological University, Singapore. She worked on oxidative stress in skin, skeletal, adipose tissue and cardiac muscle for a decade from 2006-2016. She is currently working as a Programme Management Officer handling projects and grants at Singapore Bioimaging Consortium (SBIC), Agency for Science, Technology and Research (A*STAR). Earlier to this she was a Research Fellow in the Fat Metabolism and Stem Cell Group at SBIC. Sandhya was also the Vice President and Publicity Chair of A*PECSS (A*STAR Post Doc Society) (2014-2016). Recently she founded a platform for scientists - SciGlo (www.sciglo.com) and is a startup mentor at Vertical VC (Finland). She is an ardent lover of science and enjoys globe trotting and good vegetarian food.

3 COMMENTS

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